Manchester United will face a Manchester City side who are unbeaten in nine Premier League games and will be without two of their best players.
Man City are undefeated in their last nine Premier league games and face the prospect of losing out on a fourth straight Champions League spot if they cannot secure the three points they need to secure Champions League qualification.
The tie will be played on the weekend of October 26 and will see Manchester United travel to Old Trafford in the Premier League’s return fixture.
Manchester City will be looking to secure their first away victory in the competition since the end of the 2014-15 season after they took all three points from the first leg.
United have won just one of their last 10 games and are now without top scorer Sergio Aguero who is still out with a knee injury.
The Argentine striker has scored three goals and assisted two others in the last three Premier League matches.
City have won only three of their nine Premier football matches and have not won since January.